解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::It has been estimated that the sister plant pathogenic fungal species Heterobasidion irregulare and Heterobasidion annosum may have been allopatrically isolated for 34-41 Myr. They are now sympatric due to the introduction of the first species from North America into Italy, where they freely hybridize. We used a compa...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv209
更新日期:2015-11-01 00:00:00
abstract::The process of transcription is highly stochastic leading to cell-to-cell variations and noise in gene expression levels. However, key essential genes have to be precisely expressed at the correct amount and time to ensure proper cellular development and function. Studies in yeast and bacterial systems have shown that...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv179
更新日期:2015-09-04 00:00:00
abstract::The evolution of heterogametic sex chromosomes is often-but not always-accompanied by the evolution of dosage compensating mechanisms that mitigate the impact of sex-specific gene dosage on levels of gene expression. One emerging view of this process is that such mechanisms may only evolve in male-heterogametic (XY) s...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv156
更新日期:2015-09-02 00:00:00
abstract::Sex determination evolves rapidly, often because of turnover of the genes at the top of the pathway. The house fly, Musca domestica, has a multifactorial sex determination system, allowing us to identify the selective forces responsible for the evolutionary turnover of sex determination in action. There is a male dete...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv128
更新日期:2015-07-02 00:00:00
abstract::Taeniid cestodes (including the human parasites Echinococcus spp. and Taenia solium) have very few mobile genetic elements (MGEs) in their genome, despite lacking a canonical PIWI pathway. The MGEs of these parasites are virtually unexplored, and nothing is known about their expression and silencing. In this work, we ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv126
更新日期:2015-07-01 00:00:00
abstract::Evolutionary interactions across levels of biological organization contribute to a variety of fundamental processes including genome evolution, reproductive mode transitions, species diversification, and extinction. Evolutionary theory predicts that so-called "selfish" genetic elements will proliferate when the host e...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv116
更新日期:2015-06-24 00:00:00
abstract::Genome reduction is a hallmark of symbiotic genomes, and the rate and patterns of gene loss associated with this process have been investigated in several different symbiotic systems. However, in long-term host-associated coevolving symbiont clades, the genome size differences between strains are normally quite small ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv108
更新日期:2015-05-28 00:00:00
abstract::Many algal groups acquired complex plastids by the uptake of green and red algae through multiple secondary endosymbioses. As a result of gene loss and transfer during the endosymbiotic processes, algal endosymbiont nuclei disappeared in most cases. However, chlorarachniophytes and cryptophytes still possess a relict ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv096
更新日期:2015-05-22 00:00:00
abstract::Pathogens and hosts are in an ongoing arms race and genes involved in host-pathogen interactions are likely to undergo diversifying selection. Fusarium plant pathogens have evolved diverse infection strategies, but how they interact with their hosts in the biotrophic infection stage remains puzzling. To address this, ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv092
更新日期:2015-05-19 00:00:00
abstract::Because natural selection is likely to act on multiple genes underlying a given phenotypic trait, we study here the potential effect of ongoing and past selection on the genetic diversity of human biological pathways. We first show that genes included in gene sets are generally under stronger selective constraints tha...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv083
更新日期:2015-05-13 00:00:00
abstract::All living organisms require protein degradation to terminate biological processes and remove damaged proteins. One such machine is the 20S proteasome, a specialized barrel-shaped and compartmentalized multicatalytic protease. The activity of the 20S proteasome generally requires the binding of regulators/proteasome a...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv068
更新日期:2015-05-04 00:00:00
abstract::Alternative splicing and gene duplication are the two main processes responsible for expanding protein functional diversity. Although gene duplication can generate new genes and alternative splicing can introduce variation through alternative gene products, the interplay between the two processes is complex and poorly...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv076
更新日期:2015-04-29 00:00:00
abstract::Within plastid-bearing species, the mutation rate of the plastid genome is often assumed to be greater than that of the mitochondrial genome. This assumption is based on early, pioneering studies of land plant molecular evolution, which uncovered higher rates of synonymous substitution in plastid versus mitochondrial ...
journal_title:Genome biology and evolution
pub_type: 信件
doi:10.1093/gbe/evv069
更新日期:2015-04-13 00:00:00
abstract::Klebsiella pneumoniae clonal group (CG) 258, comprising sequence types (STs) 258, 11, and closely related variants, is associated with dissemination of the K. pneumoniae carbapenemase (KPC). Hospital outbreaks of KPC CG258 infections have been observed globally and are very difficult to treat. As a consequence, there ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv062
更新日期:2015-04-10 00:00:00
abstract::OAS (2'-5'-oligoadenylate synthases) proteins and cyclic GMP-AMP synthase (cGAS, gene symbol: MB21D1) patrol the cytoplasm for the presence of foreign nucleic acids. Upon binding to double-stranded RNA or double-stranded DNA, OAS proteins and cGAS produce nucleotide second messengers to activate RNase L and STING (sti...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv046
更新日期:2015-03-09 00:00:00
abstract::The question on the patterns and limits of reduction of plastid genomes in nonphotosynthetic plants and the reasons of their conservation is one of the intriguing topics in plant genome evolution. Here, we report sequencing and analysis of plastid genome in nonphotosynthetic orchids Epipogium aphyllum and Epipogium ro...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv019
更新日期:2015-01-28 00:00:00
abstract::The loss of Y-linked genes during sex chromosome evolution creates a potentially deleterious low gene dosage in males. Recent studies have reported different strategies of dosage compensation. Unfortunately, most of these studies investigated taxa with comparatively old sex chromosome systems, which may limit insights...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv013
更新日期:2015-01-23 00:00:00
abstract::Sex chromosomes have evolved independently in many different taxa, and so have mechanisms to compensate for expression differences on sex chromosomes in males and females. Different clades have evolved vastly different ways to achieve dosage compensation, including hypertranscription of the single X in male Drosophila...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv008
更新日期:2015-01-18 00:00:00
abstract::The genome of the bladderwort Utricularia gibba provides an unparalleled opportunity to uncover the adaptive landscape of an aquatic carnivorous plant with unique phenotypic features such as absence of roots, development of water-filled suction bladders, and a highly ramified branching pattern. Despite its tiny size, ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu288
更新日期:2015-01-09 00:00:00
abstract::Although heterokaryons have been reported in nature, multicellular organisms are generally assumed genetically homogeneous. Here, we investigate the case of arbuscular mycorrhizal fungi (AMF) that form symbiosis with plant roots. The growth advantages they confer to their hosts are of great potential benefit to sustai...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv002
更新日期:2015-01-07 00:00:00
abstract::Mitochondrial (mt) genomes are intensively studied in Ascomycota and Basidiomycota, but they are poorly documented in basal fungal lineages. In this study, we sequenced the complete mtDNA of Rhizophagus sp. DAOM 213198, a close relative to Rhizophagus irregularis, a widespread, ecologically and economical relevant spe...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu268
更新日期:2014-12-19 00:00:00
abstract::Whole-genome duplications are radical evolutionary events that have driven speciation and adaptation in many taxa. Higher-order polyploids have complex histories often including interspecific hybridization and dynamic genomic changes. This chromosomal reshuffling is poorly understood for most polyploid species, despit...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu261
更新日期:2014-12-04 00:00:00
abstract::Nemerteans are one of few animal groups that have evolved the ability to utilize toxins for both defense and subduing prey, but little is known about specific nemertean toxins. In particular, no study has identified specific toxin genes even though peptide toxins are known from some nemertean species. Information abou...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu258
更新日期:2014-11-27 00:00:00
abstract::Neotropical primates (NP) are presently distributed in the New World from Mexico to northern Argentina, comprising three large families, Cebidae, Atelidae, and Pitheciidae, consequently to their diversification following their separation from Old World anthropoids near the Eocene/Oligocene boundary, some 40 Ma. The ev...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu244
更新日期:2014-11-05 00:00:00
abstract::The family Actinomycetaceae comprises several important pathogens that impose serious threat to human health and cause substantial infections of economically important animals. However, the phylogeny and evolutionary dynamic of this family are poorly characterized. Here, we provide detailed description of the genome c...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu211
更新日期:2014-09-22 00:00:00
abstract::The oldest contemporary human mitochondrial lineages arose in Africa. The earliest divergent extant maternal offshoot, namely haplogroup L0d, is represented by click-speaking forager peoples of southern Africa. Broadly defined as Khoesan, contemporary Khoesan are today largely restricted to the semidesert regions of N...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu202
更新日期:2014-09-10 00:00:00
abstract::The genus Campylobacter includes some of the most relevant pathogens for human and animal health; the continuous effort in their characterization has also revealed new species putatively involved in different kind of infections. Nowadays, the available genomic data for the genus comprise a wide variety of species with...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu195
更新日期:2014-09-04 00:00:00
abstract::Determining the rate of protein evolution and identifying the causes of its variation across the genome are powerful ways to understand forces that are important for genome evolution. By using a multitissue transcriptome data set from great tit (Parus major), we analyzed patterns of molecular evolution between two pas...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu157
更新日期:2014-08-01 00:00:00
abstract::Rapid divergence of gene copies after duplication is thought to determine the fate of the copies and evolution of novel protein functions. However, data on how long the gene copies continue to experience an elevated rate of evolution remain scarce. Standard theory of gene duplications based on some level of genetic re...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu159
更新日期:2014-07-28 00:00:00
abstract::The universal genetic code defines the translation of nucleotide triplets, called codons, into amino acids. In many Saccharomycetes a unique alteration of this code affects the translation of the CUG codon, which is normally translated as leucine. Most of the species encoding CUG alternatively as serine belong to the ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu152
更新日期:2014-07-22 00:00:00
abstract::We determined the complete mitochondrial (mt) genomes of three evaniomorph species, Ceraphron sp. (Ceraphronoidea), Gasteruption sp. (Evanioidea), and Orthogonalys pulchella (Trigonalyoidea) as well as the nearly complete mt genome from another evaniomorph species, Megalyra sp. (Megalyroidea). Each of them possesses d...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu145
更新日期:2014-07-01 00:00:00
abstract::DNA methylation and chromatin states play key roles in development and disease. However, the extent of recent evolutionary divergence in the human epigenome and the influential factors that have shaped it are poorly understood. To determine the links between genome sequence and human epigenome evolution, we examined t...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu142
更新日期:2014-06-24 00:00:00
abstract::The chloroplast is an essential plant organelle responsible for photosynthesis. Gene duplication, relocation, and loss in the chloroplast genome (cpDNA) are useful for exploring the evolution and phylogeny of plant species. In this study, the complete chloroplast genome of Paris verticillata was sequenced using the 45...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu138
更新日期:2014-06-19 00:00:00
abstract::Bacteria of the genus Xenorhabdus are symbionts of soil entomopathogenic nematodes of the genus Steinernema. This symbiotic association constitutes an insecticidal complex active against a wide range of insect pests. Unlike other Xenorhabdus species, Xenorhabdus poinarii is avirulent when injected into insects in the ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu119
更新日期:2014-06-05 00:00:00
abstract::The Piwi-interacting RNA (piRNA) pathway is responsible for germline specification, gametogenesis, transposon silencing, and genome integrity. Transposable elements can disrupt genome and its functions. However, piRNA pathway evolution and its adaptation to transposon diversity in the teleost fish remain unknown. This...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu105
更新日期:2014-05-19 00:00:00
abstract::Acquisition of Elizabethkingia infections in intensive care units (ICUs) has risen in the past decade. Treatment of Elizabethkingia infections is challenging due to the lack of effective therapeutic regimens, leading to a high mortality rate. Elizabethkingia infections have long been attributed to Elizabethkingia meni...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu094
更新日期:2014-05-06 00:00:00
abstract::Mitochondrial interactions with the nuclear genome represent one of life's most important co-evolved mutualisms. In many organisms, mitochondria are maternally inherited, and in these cases, co-transmission between the mitochondrial and nuclear genes differs across different parts of the nuclear genome, with genes on ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu063
更新日期:2014-05-01 00:00:00
abstract::Salmonella enterica subsp. enterica serovar Heidelberg (S. Heidelberg) is one of the top serovars causing human salmonellosis. Recently, an antibiotic-resistant strain of this serovar was implicated in a large 2011 multistate outbreak resulting from consumption of contaminated ground turkey that involved 136 confirmed...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu079
更新日期:2014-05-01 00:00:00
abstract::Although pooled-population sequencing has become a widely used approach for estimating allele frequencies, most work has proceeded in the absence of a proper statistical framework. We introduce a self-sufficient, closed-form, maximum-likelihood estimator for allele frequencies that accounts for errors associated with ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu085
更新日期:2014-04-30 00:00:00
abstract::The Arabidopsis DA1 genes appear to have multiple functions in regulating organ size and abiotic stress response, but the biological roles of its closely related genes remain unknown. Evolutionary analyses might provide some clues to aid in an understanding of their functional diversification. In this work, we charact...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu076
更新日期:2014-04-01 00:00:00